Symptoms are often not noticed until adolescence or adulthood. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery. Home; Map; Forum; Stats; Stories ; Top questions; Advice; Diseasemaps; Close; Join th 3.1 Physical Symptoms. {ref34} The 47,XXY karyotype of Klinefelter syndrome … What causes Klinefelter syndrome? See some of the causes of Klinefelter Syndrome according to people who have experience in Klinefelter Syndrome. Cause of Klinefelter syndrome So this question is asking if the effects of Klein filter syndrome, which is when the male has xx Why, ah syndrome are compared to the effects of down syndrome. Many boys and men don’t realize they have Klinefelter syndrome. Also called XXY syndrome, the condition interferes with the development and function of your testes and contributes to hypogonadism and low testosterone. The condition is primarily caused by the genetic mutation or the acquisition of male born babies of an extra X sex chromosome. Klinefelter syndrome … Symptoms & causes; Diagnosis & treatment; Doctors & departments; Print. Individuals with this condition tend to present as tall, phenotypic men with small testes, decreased body hair, gynecomastia, and infertility. • The children who are suffering from this syndrome tend to become taller than average. Klinefelter Syndrome . In 1959, Klinefelter syndrome was found to be caused by a supernumerary X chromosome in a male. This results in a sperm … As many as two-thirds of men with the syndrome may never be diagnosed. Most often, boys and men with Klinefelter syndrome have the usual X and … The existence of an extra X chromosome takes place when the genetic element splits unevenly in the egg. This order is so if we go throughout, just due process over one of elimination. However, they are more obedient and helpful as compared to the others. Other associated Klinefelter syndrome signs and symptoms can include. When you can get a whole picture portraying the person's chromosomes, that is called Karyotype. When you can get a whole picture portraying the person's chromosomes, that is called Karyotype. Sections for Klinefelter syndrome. Klinefelter syndrome is associated with decreased levels of testosterone and is the most common cause of congenital hypogonadism. In many cases, it’s only detected if a man with Klinefelter syndrome undergoes fertility tests. Then, Dr. Jacobs and his research team found out that it was due to an extra X chromosome (1). Some people are affected only very mildly, while for others it has more … Treatment. Klinefelter syndrome symptoms. Often, symptoms are subtle and subjects do not realize they are affected. Article Translations: What Is Klinefelter Syndrome? • In children, muscles are weaker and strength is reduced. It's a genetic condition (meaning a person is born with it). Their karyotype is 47,XXY.. Toggle navigation. Many males are not diagnosed until puberty or adulthood. Klinefelter Syndrome Karyotype. The extra X chromosome can be from the mother or the father and occurs with about the same frequency. Approximately 3% of all infertile men have Klinefelter syndrome and 14% of non-obstructive azoospermic men have Klinefelter syndrome. Klinefelter Syndrome often referred to as XXY trisomy, XXY syndrome, and Klinefelter’s Syndrome is a chromosomal disorder exclusively associated with males having one or more of the X chromosome than the normal ‘XY’ pattern. Signs and symptoms can vary. Although this is one of the genetic disorders, it is not carried through family members. If there happens to be any alteration in the Karyotype can result in abnormal behaviour within the chromosomes and, therefore, causing Klinefelter syndrome. Males with Klinefelter syndrome have at least one extra X chromosome (47, XXY). While KS individuals have an extra X chromosome making the total number of … What causes Klinefelter’s syndrome? Klinefelter syndrome happens when a male is born with an additional X chromosome. Klinefelter's Syndrome (KS) is a sex chromosomal disorder like Turner’s syndrome. Natural History: Klinefelter syndrome is a chromosomal condition that affects male physical and cognitive development. The symptoms of this condition which impedes cognitive and physical development vary from one affected person to another. Klinefelter syndrome only affects males. If there happens to be any alteration in the Karyotype can result in abnormal behaviour within the chromosomes and, therefore, causing Klinefelter syndrome. Klinefelter syndrome (KS), likewise known as 47 XXY, or Klinefelter-Reifenstein-Albright syndrome or XXY Syndrome, is a common genetic condition that affects 1 in every 1000 live male births. So you have a which is more severe than down syndrome due to jean delusions and down Syndrome. Klinefelter syndrome is a sex chromosome disorder in boys and men that results from the presence of an extra X chromosome in cells. Klinefelter syndrome is one of the leading causes of male infertility. Causes. Klinefelter syndrome babies are quieter and less demanding than other babies. What causes Klinefelter syndrome? 2002;61:49–53. Klinefelter syndrome can cause problems with learning and sexual development in guys. Early recognition and hormonal treatment of the disorder can substantially improve quality of life and prevent serious consequences. Generally, individuals suffering from this condition live to nearly the same age as healthy people. Klinefelter syndrome occurs when a boy is born with one or more extra X chromosomes. The more the number of X chromosomes in … However, it is thought to be a variety of reasons including hormones, learning difficulties, social pressures, and physical illness. Most men with Klinefelter syndrome lead the same sort of lives as everybody else. 3.1.1 During First year of life: 3.1.2 For boys aged 5 years and above: 3.1.3 At puberty or adolescent stage: 3.1.4 Adult males with Klinefelter Syndrome manifest the following: 3.1.5 Also, males with Klinefelter syndrome are more prone to developing: While Klinefelter syndrome is genetic (in that it involves an extra X chromosome), it is not usually hereditary in the conventional sense. As discussed earlier, Klinefelter’s syndrome arises due to an extra X chromosome. What are the signs and symptoms of Klinefelter syndrome? What causes Klinefelter syndrome? Klinefelter Syndrome Karyotype. Klinefelter Syndrome is not an inherited disorder, and It is a disorder caused by a defect in chromosomes. It can also develop when the genetic element splits unevenly in the sperm. Klinefelter syndrome (KS), also known as 47,XXY is the set of symptoms that result from two or more X chromosomes in males. In this case, two X chromosomes or X and Y chromosomes fail to separate. Klinefelter Syndrome – Life Expectancy. The addition occurs in the sperm, the egg, or after conception. This results in smaller-sized testicles, low testosterone levels, and possibly infertility. Most often, all the cells of an individual will have that extra copy of the X chromosome and that is what interferes with male sexual development and causes the features of Klinefelter syndrome. The effects of having an additional chromosome are abnormalities in the normal development of the body, hypogonadism, and male infertility. The major cause of Klinefelter syndrome is the variation in genes. Clin Genet. breast enlargement in men, delayed puberty, flaccid muscles, infertility, low-set ears, osteoporosis, low energy level, reduced sex drive, and; a small penis. Klinefelter's syndrome is the most common genetic cause of human male infertility, but many cases remain undiagnosed because of substantial variation in clinical presentation and insufficient professional awareness of the syndrome itself. Normally, males have the XY sex chromosome, determining them of their sex. Departments and specialties. Causes Of Klinefelter Syndrome. Klinefelter syndrome is a genetic disorder that causes males to have an extra X chromosome. Causes of Psychological Problems in Klinefelter Syndrome. What are the signs and symptoms of Klinefelter syndrome? Klinefelter syndrome was originally described by Dr. Klinefelter back in 1942. World map of Klinefelter Syndrome View more. At that time, they didn’t know the cause and suspected it was only a hormonal problem. So let's do this. See some of the causes of Klinefelter Syndrome according to people who have experience in Klinefelter Syndrome. Klinefelter Syndrome Causes & risk factors. Most boys and men have one X and one Y sex chromosome. Symptoms Of Klinefelter Syndrome . Klinefelter syndrome is the most frequent sex chromosome abnormality and is seen in about 150 boys out of every 100,000 live-born boys. The extra x chromosome is retained at the time of gametogenesis (meiosis 1) due to non-dysfunction. The most common symptom of Klinefelter syndrome is infertility, which often isn't noticed until adulthood. That is, Klinefelter syndrome is not inherited, nor does it "run in families." People typically have 46 chromosomes in each cell, two of which are the sex chromosomes. Females have two X chromosomes (46,XX), and males have one X and one Y chromosome (46,XY). Klinefelter syndrome doesn’t usually cause any obvious symptoms early in childhood, and even the later symptoms may be difficult to spot. The syndrome is not inherited from the parents. 2 Klinefelter Syndrome Causes; 3 Klinefelter Syndrome Symptoms. Klinefelter syndrome can cause many different complications, like anxiety, depression, low self-esteem, emotional immaturity, impulsiveness, weak bones, heart/blood vessel disease, lung disease, breast cancer, other cancers, infertility, problems with sexual function, metabolic syndrome, autoimmune disorders, dental problems, and autism spectrum disorder. Klinefelter Syndrome. When it comes to Klinefelter syndrome, the infant has XXY as their sex chromosome. Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Klinefelter syndrome is a genetic disease that causes males to be born with an extra copy of the X chromosome in their cells. The primary features are infertility and small poorly functioning testicles. 9. Klinefelter Syndrome Symptoms. Speech and Learning Problems. This extra chromosome arises from the accidental retention of a chromosome during a non-disjunction event during paternal and maternal Meiosis I (Gametogenesis). It is not clear why this happens. As they grow older, they develop into less confident, less active, and shy individuals, who find it difficult to cope up with or fit in with children their age. Klinefelter syndrome is a common cause for mental retardation of unknown etiology among prepubertal males. Klinefelter syndrome (KS), also known as XXY syndrome, is a genetic cause of male infertility.Children born with this genetic disease have an extra X chromosome, hence the name. However, early death can result from iatrogenesis (complications arising from medicinal or cultural interventions, like surgeries or extreme rituals). It is not known what makes XXY boys and men more prone to psychological problems and aggression. 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